| LEONOV | Cosmonaut Aleksei who performed the first space walk |
| SPACEWALK | The first one was performed by Aleksei Leonov on 3/18/1965 |
| WALKINSPACE | What was Aleksei Leonov the first to do? (4,2,5) |
| BESSEL | Who performed the first accurate measurement of the distance to a star and predicted the existence of Neptune (6) |
| BARNARD | Christiaan, South African surgeon who performed the first human heart transplant (7) |
| SPACEAGE | The age beginning with the first space travel; from 1957 to the pres (5,3) |
| EXPLORER | Name for the first space satellite orbited by the United States, in 1958, and any of the largest series of uncrewed U.S. spacecraft, consisting of 55 scientific satellites launched between 1958 and 19 |
| SKYLAB | The first space station operated by the US, 1973 to 1979 (6) |
| TITO | Dennis, U.S. businessman who became the first 'space tourist' in 2001 (4) |
| THOLE | The first space or pin to keep oar in place (5) |
| MARS | Mariner 9 was the first space probe to orbit this planet, in 1971 (4) |
| DIDDLES | Cheats the French having performed the first dance before them (7) |
| AUMERLE | In 4.1, this character is accused of being involved in "noble Gloucester's death, Who wrought it with the King, and who performed The bloody office of his timeless end." Who is it? |
| INTROIT | At home, trio performed the first psalm (7) |
| PROMENADE | Expert performed outside space walk (9) |
| ENDEAVOUR | First space shuttle to visit the International Space Station (9) |
| JOHN | Elton who performed "The Circle of Life" with the Broadway cast of "The Lion King" on its 20th anniversary |
| STERN | Violinist Isaac who performed the solos in the movie "Fiddler on the Roof" |
| AHA | Pop group who performed the title song of the 1987 James Bond movie The Living Daylights (1-2) |
| TOMJONES | Singer who performed the title song to the fourth James Bond movie, the 1965 Thunderball (3,5) |
