| TURA | Cosme ___, 15th-century Renaissance painter |
| FRA | ___ Angelico (15th-century Renaissance painter) |
| RIVERA | Cosme, Mexican boxer who lost to Zab Judah in a World Welterweight title fight in 2005 (6) |
| ANGELICO | Fra ___ , 15th century early Renaissance painter (8) |
| EYCK | Jan van ___ (15th-century Flemish painter) |
| PRESS | Printing ___ (15th-century invention of Johannes Gutenberg) |
| ROSES | Wars of the ___, 15th-century civil conflict (5) |
| ARC | Joan of ___, 15th-century French heroine (3) |
| CAXTON | William ___, 15th-century merchant and print innovator (6) |
| DIAZ | Bartholomew ___, 15th century Portuguese explorer (4) |
| CABOT | John _, 15th-century Italian explorer (5) |
| DUNSTABLE | John ___, 15th-century English composer (9) |
| LASTSUPPER | The ___, 15th-century mural by Leonardo da Vinci (4,6) |
| CENACOLO | Il ___, 15th-century mural by Leonardo da Vinci also known as The Last Supper |
| GUTENBERG | Johannes ___, 15th-century pioneer of moveable type printing, based in Mainz (9) |
| HARLEM | Neighborhood with an early 20th- century Renaissance |
| SUSATO | Tielman ___, Antwerp-based 16th-century Renaissance composer, instrumentalist and music publisher |
| BUCHANAN | James _; 15th US president (8) |
| PIERODELLAFRANCESCA | 15th-century Italian Renaissance painter |
| MELOZZO | ? da Forli, 15th-century Italian Renaissance painter whose works include fresco Sixtus IV Appointing Platina as Prefect of the Vatican Library (7) |
