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20 answers for: Constantine the Great's second wife
RANKANSWERCLUE
FAUSTAConstantine the Great's second wife
BYZANTINEEMPIREConstantine the Great's domain
NISConstantine the Great's birthplace
LABARUMMonogrammed with the chi-rho symbol, the imperial standard of Constantine the Great (7)
FLAVIUSFirst name of the Roman emperor Constantine the Great
NISHBirthplace of Constantine the Great
RHOChi-___ (military insignia for Constantine the Great)
HELENARoman empress and mother of Constantine the Great (6)
CCCVIYear Constantine the Great became emperor
STHELENAMother of Constantine the Great (and eponym of a South Atlantic island)
ARCHIn Rome there's one each for Titus, Septimius and Constantine; the Marble one's in London
OPIEPainter in the chiaroscuro manner who was introduced to London as the "Cornish wonder" by John Wolcot and, at the end of his life, buried among the greats in St Paul's Cathedral (4)
GRAVESTFive of the greats are the most sober
EPITHETWhat is the linguistic term for "the Great" in Catherine the Great's name? (7)
SWEDENCountry that lost its supremacy as a superpower in the Baltic region to Peter the Great's Russia following disastrous participation in the Great Northern War (6)
TITIANA giant one among the greats of the art world? (6)
DORISWhat was the name of Herod the Great's first wife? (5)
ALEXANDEROne of the greats from ten included in a list — wine from the south
STAGERImpresario to the greats
HURONLake ___ (It's one of the Greats)