| CRYOGENIC | Concerned with creating ultra-low temperatures (9) |
| CRYOSLEEP | Hibernation at ultra-low temperatures, in sci-fi |
| FROSTBITE | Skin injury commonly affecting extremities in low temperatures (9) |
| FREEZEDRY | Use low temperatures to dehydrate (6-3) |
| CRYOMETER | Thermometer for low temperatures |
| BORDERING | Approaching mass of low temperature air (4,5) |
| MOOTPOINT | Low temperature affected Pinot? Bone of contention (4,5) |
| RING | Abbr. for Ultra Low Emission Vehicle (1,1,1,1) |
| ULF | Ultra Low Frequency |
| SPIRITAIRLINES | Ultra-low-cost carrier |
| LEAVENALONE | Ultra-low-carb, gluten-free bread? |
| KETO | Ultra-low-carb diet, for short |
| UNION | College gets on with creating alliance (5) |
| HAMSTER | First of mice and rats he experimented with, creating relative (7) |
| SEWINGUP | Successfully dealing with creating a suture (6,2) |
| BETSY | Ross who is credited with creating the first American flag |
| WYNNE | Arthur __, credited with creating the first crossword in 1913 (5) |
| FIRSTLY | To begin with, creating a stir, jet round (7) |
| SEURAT | Georges ___, painter widely credited with creating pointillism (6) |
| EMISSIONZONE | ULEZ, acronym meaning Ultra Low _____, for an area in London to tackle pollution (8,4) |