| LEMOYNE | College in Syracuse, N.Y. |
| EDT | Summer setting in Syracuse, N.Y. |
| UTICA | Syracuse, N.Y., neighbour |
| OSWEGO | City northwest of Syracuse, N.Y. |
| RTEE | Way from Syracuse, N.Y., to Harrisburg, Pa. |
| SNOW | What Syracuse, N.Y., once jokingly attempted to outlaw, after the harsh 1991-92 winter season |
| ORANGEMEN | Colorful collegians in Syracuse NY |
| SEISM | Earthquake in Syracuse is minor |
| ERIE | Canal with a museum in Syracuse |
| SEMI | 18-wheeler hidden in "Syracuse Mile" |
| ONEIDA | Lake ... in central New York state lies N. E. of Syracuse (6) |
| BLOODORANGE | Syracuse graduate in phlebotomy? |
| DIONYSIUS | ? I, tyrant of Syracuse who died in 367 BC |
| MARCELLUS | Roman consul who captured Syracuse in A.D. 211 |
| TANCREDI | Rossini opera set in medieval Syracuse (8) |
| RAGUSA | Italian town in Sicily, southwest of Syracuse (6) |
| DROMIO | ___ of Ephesus and ___ of Syracuse, twin slaves in William Shakespeare play The Comedy of Errors (6) |
| ONONDAGA | ? Lake, body of water in central New York State north-west of Syracuse (8) |
| ARCHIMEDES | Greek mathematician and physicist of Syracuse, noted for his work in geometry, hydrostatics and mechanics (10) |
| JIMBOEHEIM | College basketball coach who has won 946 games with the Syracuse Orange as of 3/20/19: 2 wds. |