| VALLADOLID | City in northwestern Spain where Christopher Columbus died in 1506 (10) |
| OVIEDO | City in northwestern Spain that is capital of the region of Asturias (6) |
| MDVI | Year Christopher Columbus died |
| GALICIAN | Language of the Western Ibero-Romance branch spoken in an autonomous community located in northwestern Spain |
| SWISSGUARD | Infantry unit of the Vatican City founded 1506 (5,5) |
| COLUMBUS | Christopher ___, navigator and explorer who died in Valladolid, Spain in 1506 (8) |
| BAHAMAS | The ____, island group in the Atlantic where Christopher Columbus first landed in 1492 (7) |
| GENOA | Italian city where Christopher Columbus was born |
| PUGETSOUND | Deep inlet of the Pacific Ocean in northwestern Washington State, US (5,5) |
| TRISTANDACUNHA | Volcanic island group in the south Atlantic, discovered in 1506 (7,2,5) |
| TROJANS | People who lived in an ancient city in northwestern Anatolia (7) |
| GHENT | Port city in northwestern Belgium and industrial center. |
| KENORA | City in northwestern Ontario near the Manitoba border |
| MAHABAD | City in northwestern Iran whose name means "place of moon" |
| ORAN | A port city in northwestern Algeria (4) |
| ALEPPO | City in northwestern Syria located at one end of the Silk Road (6) |
| CAEN | City in northwestern France, final resting place of William the Conqueror (4) |
| BREMEN | Commercial and industrial city in northwestern Germany with a major port on the River Weser |
| ARDABIL | City in northwestern Iran, close to the border with Azerbaijan (7) |
| CADIZ | Port in southwestern Spain where in 1587 Sir Francis Drake carried out 'The Singeing of the King of Spain's Beard' |
