| CHAZ | Cher's transgender son, _ Bono (4) |
| BONO | Cher's transgender son, Chaz _ (4) |
| CHAZBONO | Transgender son of iconic celebrity Cher (4,4) |
| AVA | _ Webster is playing 29A's transgender son Ro (3) |
| ALEX | Renowned fly fishermen Charles Jardine and son ___ (4) |
| EARL | Title of Prince Edward's son, _ of Wessex (4) |
| ONLY | Gregor Fisher comedy about a Scottish father and son, _ Child (4) |
| GOUT | "Chacun a son ___" |
| OBEY | "Now therefore, my son, ___ my voice" (Ge 27:8) |
| VOLT | Alt-rock band Son ___ |
| OFAN | NOFX's "Idiot Son ___ Asshole" |
| SEAN | Patty Duke's actor son, ___ Astin |
| DESI | Lucille Ball's son, ___ Arnaz Jr. |
| BURY | "In peace, sons ___ their fathers. In war, fathers ___ their sons": Herodotus (4) |
| JAIL | Transgender teen with a TLC reality show |
| LOLA | Transgender character in a Kinks tune |
| MAYA | FIRST SOAP TRANSGENDER CHARACTER FROM A MAJOR FAMILY (B&B) |
| LGBT | (Abbreviation) Lesbian, Gay, Bisexual, and Transgender (1,1,1,1) |
| MISS | Major in transgender activism |
| ACLU | Group that defends transgender rights: Abbr. |
