| JAKEPAUL | Boxer and YouTuber who won a bout against Mike Tyson in November (4,4) |
| KAICENAT | 21-year-old YouTuber who won Streamer of the Year |
| GREEN | John ___ American author and YouTuber who wrote the best-selling novel Paper Towns |
| KSI | Rapper, boxer and YouTuber replacing Bruno Tonioli on the BGT panel (1,1,1) |
| RUM | Strange game against Mike (3) |
| KISMET | Fate conspired against Mike's time (6) |
| JOJOSIWA | "Boomerang" singer (and dancer and actress and YouTuber) |
| TOMSCOTT | YouTuber who hosts the podcast Lateral |
| SPINKS | Undefeated in all his 32 earlier fights, which boxer (Michael ___) was demolished by Mike Tyson in 91 seconds in 1988? (6) |
| FRANKBRUNO | British boxer who lost the WBC heavyweight title to Mike Tyson in 1996 (5,5) |
| EVANDERHOLYFIELD | Boxer who, after forced retirement, returned to defeat Mike Tyson in 1996 |
| TENTHROUND | When Buster Douglas knocked out Mike Tyson, in a classic 1990 bout |
| KNOCKOUTS | Decisive blows in boxing, such as that inflicted by Buster Douglas on Mike Tyson in 1991 (9) |
| DOUGLAS | Heavyweight who KO'd Mike Tyson in 1990, Buster ... (7) |
| GIVENS | Robin _ (actress who married Mike Tyson in 1988) (6) |
| BUSTERDOUGLAS | Heavyweight who beat Mike Tyson in 1990 (6,7) |
| NOBITING | Which golden rule of boxing did Mike Tyson break in his 1997 fight with Evander Holyfield? (2,6) |
| BITINGLY | "My career's gone nowhere since the Holyfield fight," grumbled Mike Tyson ___ |
| PAUL | Jake _, YouTuber who wants to fight Mike Tyson (4) |
| JOE | First name of Mr Sugg, the YouTuber who was a runner-up on Strictly in 2018 (3) |