| EILISH | Billie _, first artist born in the 2000s to top the US charts (6) |
| GEN | ___ Z (like kids born in the 2000s) |
| CLAUDE | First name of the artist born in the Duchy of Lorraine who painted Landscape with Ascanius Shooting the Stag of Sylvia (6) |
| WILKIE | Artist born in the parish of Cults, Fife in 1785 whose paintings include Pitlessie Fair, The Letter |
| CAPSULE | Spacecraft with top the United States returned to the French (7) |
| HOZIER | Which Irish singer's debut album went to number 2 in the US charts in October? (6) |
| OLIVIA | Youngest solo artist to top the UK singles and album charts simultaneously (6,7) |
| EISLER | Hanns ___, Leipzig-born composer who was one of the first artists placed on the Hollywood blacklist by the movie studio bosses |
| TRAUMA | Pain of the first artist with a university degree (6) |
| ASTHMA | Stevie in the 2000s sitcom Malcolm In The Middle suffered this breathing condition (6) |
| QUINTO | Surname of Zachary - Sylar in Heroes in the 2000s and Spock in Star Trek, 2009 (6) |
| AMAZED | Country hit that crossed over to top the pop charts |
| COSTAR | One about to leave Central American country to top the bill with someone else (2-4) |
| STARCH | To top the bill when at church needs a lot of formality (6) |
| CUBIST | Youngster joins first artist (6) |
| ROCKON | 1974 David Essex hit single that was his only US chart success |
| ATKINS | Eponymous low-carb diet popular in the 2000s (6) |
| ROEPER | Ebert's partner in the 2000s |
| NUN | Sister Luc-Gabrielle whose hit song Dominique reached the top of the US charts in 1963 was called the Singing ... |
| CATSINTHECRADLE | 1974 folk song by Harry Chapin which made it to No.1 in the US charts (4,2,3,6) |