| ROYALSOCIETY | Association founded by Charles II to promote scientific research (5,7) |
| KVPY | DST's scholarship to promote scientific research which has been merged with INSPIRE |
| ROYALOAK | Tree used by Charles II to hide from the Roundheads in 1651 (5,3) |
| LAND | The former territories in Canada granted by Charles II to the Hudson's Bay Company in 1670 (7,4) |
| RUPERTS | The former territories in Canada granted by Charles II to the Hudson's Bay Company in 1670 (7,4) |
| EXPERIMENTAL | Proceeding with scientific research, boffin briefly gets mad after one .... |
| LABORATORIES | Buildings or rooms equipped for conducting scientific research (12) |
| KNELLER | Godfrey - - -, leading portraitist of the late 17th and early 18th Centuries, court painter to monarchs from Charles II to George I (7) |
| YACHT | Sailing boat such as the coal brig "Surprise" (later "Royal Escape") that carried Charles II to freedom (5) |
| SOCIETY | Royal -; founded by Robert Boyle, Sir Christopher Wren and others and granted a royal charter by Charles II, the UK's national science academy (7) |
| JEHOVAHS | Christian sect founded by Charles Russell in 1872 , ... Witnesses (7'1) |
| RICHA | Belgian clothing company founded by Charles Rigaux in the 1950s. (5) |
| JEHOVAHSWITNESS | Member of a sect founded by Charles Taze Russell (8,7) |
| ROTARY | --- Club, a local branch of an international association founded in the US in 1905 to promote community service (6) |
| AUTOMOBILE | The --- Association, British motoring association founded in 1905 (10) |
| CABAL | Name for a group of secret intriguers. The initials of the five ministers chosen by Charles II for such a role also happen to spell that name (5) |
| APHRABEHN | English dramatist thought to have been employed by Charles II as a spy in Antwerp |
| OFFICE | Post -; private company whose foundations date back to the GPO established by Charles II in 1660 (6) |
| SPANIEL | Dog with a breed popularised by Charles II and another named after Blenheim Palace, for example; or, alluding to its reputed submissive nature, a word for a fawning person (7) |
| ASTRONOMERROYAL | Honorary title, established by Charles II in 1675, currently held by British scientist Michele Dougherty (10,5) |