| OCCASIONAL | As a colonic irrigation is once in a while (10) |
| CALAMINELOTION | A colonic ailment less constant, requiring treatment that's soothing (8,6) |
| ENEMA | Colonic irrigation |
| NOWANDTHEN | Once in a while (3,3,4) |
| ONOCCASION | Party after working once in a while (2,8) |
| ELASTIGIRL | Mom who needs to stretch her legs once in a while? |
| VERYSELDOM | Every once in a while |
| TVSPECIALS | Once in a while programming |
| OCCASIONALLY | 16dn, once in a while, in a word! (12) |
| EXAMPLE | For a model, is once enough? (7) |
| POISON | The Gestapo is once again getting involved with a toxic substance (6) |
| SPANISH | Language in which "eleven" is "once" |
| SEERED | Furious. Is once more back in seed (3,3) |
| COSINE | Is once converted into a trigonometrical term (6) |
| RARELY | Once in a while, rock-and-roll headlines at place in Dublin (6) |
| TOTIME | Occasionally, and once in a while, in other words (4,4,2,4) |
| FROMTIME | Occasionally, and once in a while, in other words (4,4,2,4) |
| ATTIMES | A little cheat, Tim, escapes once in a while (2,5) |
| LAND | Reach a place where the use of cellular telephones and other electronic devices is once again permit |
| WED | What a couple is once they've pledged "to have and to hold" one another (or "hump day" abbr.) |