| ARCHENEMY | As Holmes regarded Moriarty - time for the Last Bow? |
| EXITIUM | Curtains, the last bow (think, going out): pernicies, clades |
| EON | A long long time for the last one aboard |
| VIOLINIST | Holmes, for example - until His Last Bow? |
| SBEND | His Last Bow? It has a couple of twists and turns |
| HIS | "___ Last Bow" (1917 Sherlock Holmes story) |
| ARC | Bill covering Kreisler's last bow |
| NARCO | Buster Brown's last bow, with love (5) |
| NEALCASSADY | US writer who was the model for the character Dean Moriarty in the Jack Kerouac novel On the Road (4 |
| REICHENBACHFALLS | Location of the final altercation between Sherlock Holmes and Professor Moriarty in The Final Problem by Sir Arthur Conan Doyle (11,5) |
| VIOLIN | To which 22 Down applied "His Last Bow"? (6) |
| NEMESIS | Archenemy like Professor Moriarty for Sherlock Holmes |
| ERIN | Actress Moriarty of the Prime Video series The Boys |
| CRIME | According to Sherlock Holmes, Moriarty is the Napoleon of what? (5) |
| ZUCCO | George ___, Manchester-born actor who played Professor Moriarty in 1939 film drama The Adventures of Sherlock Holmes (5) |
| FINAL | The -- Problem, short story by Arthur Conan Doyle featuring Sherlock Holmes and Professor Moriarty (5) |
| TYPE | The face of Moriarty perhaps (4) |
| BINOMIALTHEOREM | What Moriarty well knew would upset Holmes, mostly re ambition |
| ANDREWSCOTT | Jim Moriarty in Sherlock and the priest in Fleabag (6,5) |
| LIANE | "The Husband's Secret" author Moriarty |
