| LAZAR | Archaic word for a poor and diseased person, such as one afflicted by leprosy (5) |
| LILLE | Island races wiped out (by leprosy, primarily) in small arrondissement |
| ACADEMIC | A person studying a rat and diseased mice (8) |
| ALCOHOLISM | One afflicted with this can't do without his glasses (10) |
| NERVOUS | Like one afflicted with the added elements in 17-, 24-, 53- and 65-Across? |
| INGLE | Archaic word for a fire in a room or a fireplace (5) |
| STEED | Archaic word for a horse, especially one that is spirited or swift (5) |
| REPEL | Disgust by sending back diseased person (5) |
| RIMER | An archaic word for a poet (5) |
| AILED | Failed, I lose my head and become afflicted by it (5) |
| LEPER | Diseased person (5) |
| NASAL | Has a nosy person such an accent? (5) |
| ROLES | Parts for a poor loser (5) |
| FLIPFLOP | A soggy mess of food; a blundering use of a word; a person, such as a character in Joseph Andrews, guilty of said malapropism; an alternative name for a rubber thong; or, twaddle (8) |
| RAINS | Ran off and is afflicted by falls from the sky |
| TAPIR | Animal with shirt for a poor couple |
| PUBLICENEMY | A notorious person, such as a criminal, who is regarded as a menace to others (6,5) |
| PERSONAGRATA | Fully acceptable person, such as a diplomat in a foreign country (7,5) |
| PERCAPITA | Of or for each person, such as the income of each person (3,6) |
| HANDLER | Person such as a police officer working with trained dogs; or, a boxer's coach (7) |
