| MORIARTY | Arch enemy of Sherlock Holmes (8) |
| SKELETOR | Arch-enemy of He-Man in Mattel’s Masters of the Universe media franchise |
| THEMEKON | Treen leader who was the arch-enemy of British comic book character Dan Dare (3,5) |
| SHERLOCKHOLMES | Fictional arch-enemy of Professor James Moriarty (8,6) |
| SMURF | Gargamel is the arch-enemy of which type of cartoon creature? (5) |
| VENUS | Home planet of the Mekon, arch enemy of the British comic strip hero Dan Dare (5) |
| TOM | Arch-enemy of Jerry the mouse from the cartoons |
| LEX | Mr. Luthor, arch enemy of Superman (3) |
| EVIL | Dr -, arch enemy of Austin Powers (4) |
| ERNST | ____ Blofeld, an arch-enemy of James Bond |
| FLASH | ... Gordon was the arch enemy of Ming the Merciless (5) |
| BOWSER | Arch-enemy of Mario in the video games series (6) |
| LUTHOR | Lex, arch enemy of Superman (6) |
| COYOTE | Wile E -, animated arch-enemy of the Road Runner (6) |
| LEXLUTHOR | Arch enemy of comic book character Superman (3,6) |
| MEKON | Arch-enemy of comic-book hero Dan Dare (5) |
| VOLDEMORT | Arch-enemy of Harry Potter (9) |
| STILETTO | Arch enemy? |
| WILE | In the classic cartoon, who is the arch-enemy of the Road Runner? (4,1,6) |
| ECOYOTE | In the classic cartoon, who is the arch-enemy of the Road Runner? (4,1,6) |
