| MISSION | Ambition or purpose, ... in life |
| ABSURDIST | Genre of fictional narrative concerning the experiences of characters in situations where they cannot find any inherent purpose in life (9) |
| DESTINY | Man with little purpose in life (7) |
| DYSTELEOLOGY | Assumed absence of purpose in life |
| AIM | I'm after a purpose in life |
| LOST | Lacking a purpose in life |
| USE | Sue has a purpose in life! (3) |
| RAISONDETRE | Engineering dons retire with a purpose in life (6,5) |
| DRIVE | Impulsive force; a dynamic stroke of a ball; ambition or get-up-and-go; a ride, spin or trip in a car; or, an avenue or other approach to a house (5) |
| ENDORSE | Back ambition or stagnate in empty fashion (7) |
| OWNGOAL | Personal ambition -- or self-inflicted setback? (3,4) |
| DREAM | Aspiration, ambition or ideal (5) |
| GRAIL | A cherished ambition or goal (5) |
| TOUR | Blond ambition or Sticky & Sweet, for Madonna |
| IGNOBLE | Completely lacking nobility in character or quality or purpose. |
| INCLUDE | "My purpose in life does not ___ a hankering to charm society": James Dean (7) |
| OBJECT | A tangible or material thing; a goal or purpose; or, a spectacle (6) |
| BAND | A crew, gang, pop/rock group or other ring of people, bound or tied by a common interest or purpose (4) |
| RANDOM | Lacking any definite plan or order or purpose. |
| NONCE | The present or immediate occasion or purpose (5) |
