| NICOTINE | Alkaloid is not nice, I decide (8) |
| SKELETOR | Character who said, "I am not nice, I am not kind, and I am not wonderful!" |
| CAFFEINE | Which bitter crystalline alkaloid is obtained from coffee (8) |
| CRIBBAGE | 'Crab' gibe is not nice in the game! (8) |
| QUININE | Which bitter alkaloid is used to treat malaria (7) |
| NOISOME | Working, I soon found out, by myself is not nice (7) |
| INEXACT | Nice tax arrangement is not nice at all! (7) |
| ANCIENT | Old pal, nice, I see not regularly (7) |
| ARBITER | I decide how rarebit is to be cooked (7) |
| CASTINGDIRECTOR | I decide who's taking part (7,8) |
| ATROPINE | A poisonous alkaloid found in deadly nightshade (8) |
| MORPHINE | Him? Prone to change opium alkaloid? (8) |
| SMUT | Flake of soot is not nice (4) |
| IMPRECISE | Recipe cooked with last of ham is not nice (9) |
| UGLY | Fruit, we hear, is not nice to look at (4) |
| UNPLEASANT | Planet and a sun exploding is not nice (10) |
| HEXAGON | Ion exchange is not nice, somehow (7) |
| TATTY | To throw a teetotaler in the river is not nice (5) |
| LOW | What cows do with Mark is not nice (3,4) |
| NOTE | What cows do with Mark is not nice (3,4) |
