| RAVENSYMONE | Actress in "The Cheetah Girls" and "Zenon: Girl of the 21st Century" |
| ISLANDS | ___ in the Sky 1952 sci-fi novel by Arthur C. Clarke that is set in the later half of the 21st century |
| MILLENNIUMBUG | Computer problem arising from the change in date at the start of the 21st century |
| ELENA | Author of one of The New York Times' "best books of the 21st century" ... or its narrator |
| IAN | Astbury of The Doors of the 21st Century |
| NINETEENTH | We are now in the .......... year of the 21st century (10) |
| ADELE | Singer with the best-selling album of the 21st century |
| DATASCIENTIST | "Sexiest job of the 21st century," per Harvard Business Review |
| TIMOR | ___-Leste: first new sovereign state of the 21st century |
| MMI | Start of the 21st century, debatably |
| OBAMACRAT | Certain liberal of the 21st century |
| MMII | Second year of the 21st century |
| SHREW | Water ___, mammal dubbed the "cheetah of the wetlands" for its speed and stealth |
| USHAPED | In the form of the 21st letter (1-6) |
| ACINONYX | Animal genus in the cat family (Felidae) whose sole extant member is the cheetah (8) |
| CHICAGO | The only musical to have won the Oscar for Best Picture in the 21st century (7) |
| LANCER | Eg, a member of the 21st regiment that fought at Omdurman in 1898 (6) |
| SEAHENGE | Bronze Age timber circle discovered off the coast of Norfolk in 1998, thought to date from the 21st century BC (8) |
| WOOTTON | Small town in Wiltshire, recognised for its role in military funeral repatriations in the 21st Century (5,7,7) |
| ROYAL | Small town in Wiltshire, recognised for its role in military funeral repatriations in the 21st Century (5,7,7) |
