| TONYDANZA | Actor who played the main role in TV's Who's the Boss? (4,5) |
| ZORBA | Actor Anthony Quinn played the main role in this Greek film (5) |
| CREEK | James Van Der Beek played the main role in this (Dawson's ----) |
| BOSS | TV's "Who's the ___?" |
| COLT | The main role in this movie was not male, it's said (3,4) |
| THE | The main role in this movie was not male, it's said (3,4) |
| TOBE | TV's "Who Wants ___ a Millionaire" |
| ARE | TV's "Who Do You Think You ___?" |
| BEA | TV's "Who Wants to ___ Millionaire" |
| BERNSTEIN | He and fellow investigative journalist Woodward played a main role in exposing the Watergate scandal (9) |
| IDRISELBA | Actor who played the title role in TV's Luther (5,4) |
| TED | ___ Danson actor who played the main character Sam Malone in the '80s sitcom Cheers |
| MACKAY | Fulton, Scottish actor who played the main prison officer in the TV sitcom Porridge (6) |
| DOUGRAYSCOTT | Actor who played the main antagonist in the 2000 action spy film Mission: Impossible II (7,5) |
| MONICA | Bellucci, Italian actress who played the main antagonist in the 2024 film Beetlejuice Beetlejuice (6) |
| JANELYNCH | Glee costar who played the main character's mother in the 2022 Broadway revival of 15-Across: 2 wds. |
| ARDAL | ___ O'hanlon, comic who played the main DI in 9A series 6-9 (pictured bottom) (5) |
| PRINCIPAL | Head leaves main roles. (9) |
| PLAYSTHELEAD | Has the main role producing The Star (5,3,4) |
| STARSTRUCK | Comedy series created by Rose Matafeo who also plays the main role of Jessie (10) |
