| EPHEDRA | A shrub of America and Eurasia; the source of an alkaloid used for medicinal purposes (7) |
| EUROPE | Present-day continent composed of the westward-projecting peninsulas of Eurasia. The area is bordered by the Arctic and Atlantic Oceans and the Mediterranean and Black Seas. (6) |
| EPHEDRIN | A white crystalline alkaloid used for treating asthma and hay fever (8) |
| RHUBARB | Chinese call it "the great yellow" and have grown its roots for medicinal purposes for thousands of years |
| WALLRUE | Fern of the spleenwort family of North America and Eurasia (4,3) |
| TEATREE | Member of the myrtle family that's the source of an essential oil |
| SAUSAGE | South Africa, United States of America and part of Germany make a Frankfurter (7) |
| HOUSTON | The fourth-largest city in the United States of America and the largest in Texas |
| CODEINE | White crystalline alkaloid used as an analgesic, a sedative and to relieve coughing (7) |
| SPIRAEA | A shrub of the rose family with clusters of small white or pink flowers (7) |
| BEEFTEA | Criticism linked to Trim players offering drink, for medicinal purposes (4,3) |
| QUININE | Bitter alkaloid used in tonic water (7) |
| ELM | The bark of this North American tree has long been used for medicinal purposes, slippery ... |
| NYC | City that Eric Adams has called "the Istanbul of America," "the Islamabad of America," and "the Kyiv of America," for short |
| YARROW | Plant with fern like leaves and small whitish flowers used for medicinal purposes (6) |
| PLACEBO | A medicine having no fixed medicinal purpose or healing property. (7) |
| TUNDRA | A vast, treeless zone lying between the ice cap and the timber line of North America and Eurasia (6) |
| CITRON | Fruit historically used for medicinal purposes |
| OPOPANAX | Strong smelling gum resin, formerly used for medicinal purposes (8) |
| LILAC | A shrub of the olive family; a descriptor for a shade of purple (5) |
