| OCOTILLO | A cactus-like plant of Mexico and the South West US, with scarlet tubular flowers (8) |
| JOSHUA | ___ tree, Yucca plant of Mexico and the south-west USA (6) |
| CHIA | Minty plant of Mexico and the southwest US |
| ROADRUNNES | Rapid ground cuckoo of Mexico and the south-west USA (10) |
| ARIZONA | State In the south-west USA, nicknamed the Grand Canyon State (7) |
| ALOE | Cactus-like plant |
| SUCCULENT | Cactus-like plant (9) |
| SOMBRERO | A felt or straw hat with a wide brim, traditionally worn in Mexico and South West USA (8) |
| ANTILLES | Archipelago, comprising two distinct groups, bordered by the Caribbean Sea, the Gulf of Mexico and the Atlantic Ocean (8) |
| ERIGERON | Large genus of daisy-like plants of the family Asteraceae (composites) commonly known as the fleabanes (8) |
| RYEGRASS | A hardy tufted darnel-like plant of lawn, roadside verge and rough pasture, genus Lolium perenne (3,5) |
| RIOBRAVO | Mexican name for a river on the border between Mexico and the US (3,5) |
| CAMOMILE | Daisy-like plant of the family Asteraceae (8) |
| STAPELIA | Cactus-like leafless African plant (8) |
| CARNIVAL | Kanye West's US chart topper with Ty Dolla Sign (8) |
| RINGTAIL | Name given to several creatures, including Bassariscus astutus, which inhabits arid northern Mexico and the American Southwest |
| CHOLLA | Spiny cactus of the genus Opuntia found in Mexico and the south-western US; from Spanish, 'head' or skull' (6) |
| NEWSPAIN | Former Spanish viceroyalty that included Mexico and the Philippines |
| GUAYULE | Bushy shrub in the aster family of Mexico and the southwestern US; a source of latex (7) |
| SAGUARO | Tree-sized cactus, Carnegiea gigantea, found in desert regions of Mexico and south-west US (7) |
