| ACOLUMNOFFIRE | 2017 Ken Follett bestseller set in the 16th century: 4 wds. |
| HORNETFLIGHT | 2002 Ken Follett bestseller about a dangerous air mission during World War II: 2 wds. |
| THEABBOT | 1820 Sir Walter Scott novel set in the 16th century (3,5) |
| NAM | Subject of a 2017 Ken Burns-Lynn Novick documentary, briefly |
| BOOKTHIEF | Markus Zusak's bestseller, set in World War II-era Germany: The... (4,5) |
| BLINDTIGER | 2021 Sandra Brown bestseller set in Texas during Prohibition: 2 wds. |
| THELAKEHOUSE | 2015 bestseller set in an abandoned estate by water: 3wds. |
| PUGS | Small dogs, popular in the Imperial court, brought from China to Europe in the 16th Century (4) |
| SIKH | Member of an Indian religion founded in the 16th-century (4) |
| MALI | Trading empire that flourished in western Africa from the 13th to the 16th century. (4) |
| CZAR | (One spelling of) a form of the ancient Roman imperial title, used in Russia from the 16th century (4) |
| DEMILANCE | A short, light spear of the 16th century (4-5) |
| WARE | Great Bed of ____, huge one built by a Hertfordshire carpenter in the late 16th century (4) |
| DRUMSALONGTHOHK | 1936 bestseller set during the American Revolution |
| EAGLE | Jack Higgins bestseller set during World War II, The ... Has Landed |
| CONQUISTADOR | Military leader in the Spanish conquest of the New World in the 16th century (12) |
| EARTH | The Pillars of the __, by Ken Follett (5) |
| COMA | 1977 bestseller set at Memorial Hospital |
| DELORME | Philibert -; an architect who designed the first plans of the Tuileries Palace for Catherine de' Medici in the 16th century (2,1'4) |
| THEYEOMENOFTHEGUARD | Gilbert and Sullivan opera set in the Tower of London in the 16th century (3,6,2,3,5) |
