| ERNANI | 1844 opera by Giuseppe Verdi set in 16th-century Spain |
| TUDORS | The ___, British historical drama series set in 16th century (6) |
| ILTROVATORE | Opera in four acts by Giuseppe Verdi, set in Spain (2,9) |
| ARMADA | Navy (especially that of 16th-century Spain) (6) |
| SEVENSAMURAI | 1954 film set in 16th-century Japan |
| ARAGON | The marriage of Ferdinand II of ___ to Isabella I of Castile helped unite 15th-century Spain (6) |
| PESETA | Coin in 20th-century Spain |
| DONCARLOS | Opera by Verdi set in Spain |
| NABUCCO | 1842 opera by Verdi set in Jerusalem and Babylon (7) |
| AIDA | 1871 opera by Verdi set in Egypt (4) |
| PUNCH | ___ and Judy comedy duo had their origins in 16th-century commedia dell'arte and were still in popular in the 19th century as puppets. |
| THETUDORS | BBC period drama set primarily in 16th-century England (3,6) |
| GARGANTUA | Giant in 16th-century work by Rabelais (9) |
| LECID | Massenet opera set in 11th-century Spain |
| SEAPOWER | 16th-century Spain, for one |
| AMRITSAR | Central city of the Sikh religion, founded in 16th-century Punjab, NW India, by the guru Ram Das (8) |
| LADDERS | Classic children's game originating in 16th century India, Snakes And ... |
| DRAGOON | In 16th-century Europe, what was a mounted infantryman armed with a carbine? (7) |
| THREEUNITIES | Action, time and place as "Aristotelean" dramatic principles, devised in 16th-century Italy |
| GALLIARD | Gillard a mess in 16th century dance? (8) |
