| EASTERSUNDAY | 17th April 2022 (6,6) |
| CNN | ___+ (streaming service that launched in March, 2022, and shut down in April, 2022) |
| GOODFRIDAY | 15th April 2022 (4,6) |
| BELLAHADID | Supermodel on the April 2022 cover of "Vogue" |
| SHEHBAZ | Prime minister of Pakistan who succeeded Imran Khan on 11 April 2022 (7) |
| SHARIF | Prime minister of Pakistan who succeeded Imran Khan on 11 April 2022 (6) |
| ABAZOVIC | Prime minister of Montenegro who succeeded Zdravko Krivokapic on 28 April 2022 (6,8) |
| DRITAN | Prime minister of Montenegro who succeeded Zdravko Krivokapic on 28 April 2022 (6,8) |
| ESSENCE | Magazine whose March/April 2022 cover featured Niecy Nash and Jessica Betts |
| UNLIMITEDLOVE | Red Hot Chili Peppers album that debuted at #1 in April 2022: 2 wds. |
| ETSY | Online craft marketplace whose treatment of sellers was protested by a strike in April, 2022 |
| BORDERLAND | Which Hollywood movie was being filmed in Edinburgh in April 2022? (10) |
| LIAMNEESON | Star of the action thriller "Memory," about an assassin suffering from Alzheimer's (April, 2022) |
| JONBATISTE | Musician whose "We Are" took home the Album of the Year Grammy (April, 2022) |
| JAZMINESULLIVAN | Singer whose "Heaux Tales" won the Grammy for Best R. & B. Album (April, 2022) |
| BENNETT | Singer Tony who was given a tribute performance at the Grammys by his "Love for Sale" collaborator, Lady Gaga (April, 2022) |
| SILK | ___ Sonic (superduo whose debut single, "Leave the Door Open," won the Grammy for Song of the Year in April, 2022) |
| UNION | Amazon Labor ___ (worker-led group founded in April, 2022) |
| EGAN | Jennifer who wrote "A Visit from the Goon Squad" and its follow-up, "The Candy House" (April, 2022) |
| OCEAN | Vuong who wrote the elegiac poetry collection "Time Is a Mother" (April, 2022) |
