| CONQUISTADOR | 16th-century Spanish adventurer in Mexico and Peru (12) |
| CHELA | Claw of an arthropod (and popular slang term for Beer in Mexico and Peru) |
| THEGREATWALL | 2016 monster movie with Willem Dafoe as a European adventurer in China: 3 wds. |
| CONQUISTADORS | Spanish conquerors, especially those who led the conquest of Mexico and Peru in the 16th century (13) |
| LAKETITICACA | Large body of water on the border of Bolivia and Peru, in the Andes (4,8) |
| SOUTHAMERICA | Continent which includes the countries of Chile and Peru (5,7) |
| ESPERANZA | Spanish word for "hope" used as a name for cities in Argentina, Mexico and Peru |
| AERO | Travel prefix with mexico and peru |
| AZTECS | Indigenous people dominant in Mexico prior to the 16th Century Spanish conquest (6) |
| PONCEDELEON | Several hundred thousand indigenous people may have been living in Florida when this Fountain of Youth-seeking Spanish adventurer first hit the beach there in 1513 (5,2,4) |
| ELDORADO | Fabled place rich in treasure sought by 16th-century Spanish explorers in South America |
| VIHUELA | 15th- and 16th-century Spanish guitar-like stringed musical instrument |
| TINTIN | Boy reporter and adventurer in comic strips by Herge from 1929 (6) |
| ELMO | Adventurer in Grouchland, in a 1999 film |
| JACAL | Wattle and daub hut with a thatched roof in Mexico and SW USA (5) |
| DOMINGO | Spanish singer who grew up in Mexico and became one of the three tenors |
| CHOLLA | Spiny cactus of the genus Opuntia found in Mexico and the south-western US; from Spanish, 'head' or skull' (6) |
| GREASE | Which film is known as Vaselina in Mexico and several other Spanish- speaking countries? (6) |
| PESOS | Currency units in Mexico and several South American countries |
| FRIJOL | Generic term for bean, especially in Mexico and the south-western USA (6) |
