| MEDICALADVANCEMENTS | 100th Anniversary! The discovery of Insulin in 1921 by Canadian researchers Banting and Best is among the greatest of these in the world: 2 wds. |
| INSULIN | It was codiscovered by Canadian researchers Banting and Best in 1921 |
| SANGER | Frederick ___, English biochemist who determined the complete amino- acid sequence of insulin in 1955; Nobel Prize for Chemistry (1958 and 1980) (6) |
| BANTINGANDBEST | Canadians who co-discovered insulin in 1921: 3 wds. |
| DUTCHELMDISEASE | Fungal disease of trees isolated in the Netherlands in 1921 by Bea Schwarz (5,3,7) |
| BLACKANDTANS | A specially recruited armed auxiliary police force sent to Ireland in 1921 by the British Government to combat Sinn Fein |
| RUR | Sci-fi play of 1921 by Karel Capek |
| DRS | Bondar, Banting and Best: Abbr. |
| ALLISTON | Ontario community (which is part of the Town of New Tecumseth) where Insulin co-discoverer Sir Frederick Banting was born in 1891 |
| DM | Diabetes caused by a relative or absolute deficiency of insulin and characterized by polyuria |
| ERREA | Italian sportswear company that currently supplies the football kit of Norwich City and MK Dons amon |
| TEXAS | State that celebrated the 100th anniversary of the discovery of oil |
| NORTHERNTOUCH | 20th Anniversary! Juno-winning hip-hop smash of 1998 by Canadian group Rascalz, featuring Kardinal Offishall, Choclair, Checkmate and Thrust: 2 wds. |
| BEATLES | Ladies and Gentlemen the... 60th Anniversary! Liverpool band which made history on "The Ed Sullivan Show" on February 9th, 1964 |
| MELLITUS | Diabetes ___ is a condition resulting from in sufficient production of insulin causing (8) |
| DEBATES | Considers omitting insulin in the early stages of diabetes treatment (7) |
| BEST | Insulin discoverers: Banting and ___ |
| MACLEOD | Scottish physiologist awarded a Nobel Prize for his role in directing the research by F. G. Banting |
| UNICO | 2017 is the 100th anniversary of this Canadian food company (since 1917) |
| UPTON | Kate, U.S. model who was the subject of the 100th anniversary Vanity Fair cover (5) |
