| MELOZZO | ? da Forli, 15th-century Italian Renaissance painter whose works include fresco Sixtus IV Appointing Platina as Prefect of the Vatican Library (7) |
| PIERODELLAFRANCESCA | 15th-century Italian Renaissance painter |
| MICHELANGELO | Italian Renaissance painter and sculptor whose works include frescos in the Sistine Chapel (12) |
| PERUGINO | Pietro ___, Italian Renaissance painter whose works include 1505's Combat of Love and Chastity (8) |
| PISANELLO | Italian Renaissance painter whose works include The Vision of St Eustace and The Virgin and Child with Saints George and Anthony Abbot |
| PAOLOVERONESE | Venice-based Italian Renaissance painter whose works include The Wedding at Cana and The Feast in the House 32 Bomber that dropped the of Levi (5,8) |
| MASACCIO | 15th-century Italian painter whose works include saints Jerome and John the Baptist (8) |
| RAPHAEL | Italian Renaissance painter whose work adorns a suite of four rooms (Stanze) in the museum complex of the Vatican (7) |
| CRANACH | Lucas ? the Elder, German Renaissance painter whose works include 1531's The Three Graces |
| ALBERTI | Leon Battista, 15th Century Italian architect whose works include part of the facade of the Santa Maria Novella in Florence (7) |
| MANTEGNA | Andrea, 15th-century Italian painter whose St. Sebastian hangs in the Louvre (8) |
| FRAFILIPPOLIPPI | 15th-century Italian painter whose Madonna and Child with Angels is in the Uffizi Gallery in Florence |
| ORTOLANO | Italian Renaissance painter born Giovanni Battista Benvenuti who works include Saint Sebastian with Saint Roch and Saint Demetrius |
| SWISS | _ Guard: mercenary unit first used by Pope Sixtus IV in the 15th Century (5) |
| LIPPI | Florentine Renaissance painter whose works include Tobias and the Angel, Apparition of the Virgin to St Bernard and Adoration of the Magi (5) |
| LEONARDODAVINCI | Italian Renaissance painter, sculptor, architect and engineer whose paintings include The Virgin of the Rocks and the Mona Lisa |
| ERCOLE | 15th-century Italian painter, ___ de'roberti |
| UCCELLO | 15th century Italian painter |
| CABOT | John ?, 15th-century Italian explorer of the coast from Nova Scotia to Newfoundland (5) |
| JOHNCABOT | 15th Century Italian navigator and explorer, early European traveller to the North American mainland (4,5) |
