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There are 4 clues with the answer 'USIS'
# CLUE
1.
"Hmmm, it seems that one of ___ ___ missing . . . " (Observation after a head count when all heads haven't been counted)
2.
"Hmmm, it seems that one of ___ ___ missing..." (Observation after a head count when all heads haven't been counted)
3.
United States Information Service, acronym?
4.
Former D.C. agency