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There are 4 clues with the answer 'SUGARSTHEPILL'
# CLUE
1.
Makes it easier to swallow as laughter slips out (6,3,4)
2.
Makes an unpleasant or painful experience more palatable (6,3,4)
3.
Mitigates impact of huge rats running amok aboard lighter (6,3,4)
4.
Makes something unpleasant more agreeable (6,3,4)