Across and Down

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There are 28 clues with the answer 'PUFFER'
# CLUE
1.
To deter predators from eating it, this fish contains tetraodontoxin in its internal organs (6)
2.
(& 24-across) Quilted coat (6,6)
3.
Smoker who is short of breath? (6)
4.
Asthmatic's inhaler
5.
Asthmatic aid, at times
6.
Seabird leaving home has little hesitation to get fish
7.
Train to be a smoker? (6)
8.
Fish that inflates when threatened, a delicacy but some parts poisonous (6)
9.
One who smokes no longer employed on most railways (6)
10.
Peru's mad, importing very loud locomotive
11.
Globe fish
12.
Person smoking a fish
13.
Train smoker is 27 28 (6)
14.
Blowfish
15.
Train serpent not to increase (6)
16.
Perhaps Thomas gets TV medical series after praise from publicist (6)
17.
Smoker - globefish (6)
18.
Globefish - steam train? (6)
19.
Pipe-smoker in an old train?
20.
Organ
21.
Bonnie partner with promoter making 20h like the Vital Spark (5,6)
22.
About to flip after exaggerated praise for type of bony fish (6)
23.
One who smokes fish (6)
24.
Marine creature also called a globefish (6)
25.
Word for a locomotive that chugs or chuffs along; a Scottish steamboat; a fish that inflates into the shape of a balloon/globe; one who loudly blows, exhales, gasps or pants; or, an inhaler (6)
26.
Pipe smoker in an old train? (6)
27.
Fish that contains a deadly poison
28.
Fish that inflates when threatened