Across and Down

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There are 14 clues with the answer 'OPIUMDENS'
# CLUE
1.
Work with one university doctor starts to explore new systems in drug centres
2.
Smoking joints, surprisingly minus dope
3.
Smoking joints, surprisingly minus dope (5,4)
4.
Places to smoke a poppy drug
5.
Source of pipe-dreams?
6.
High spots in old China?
7.
Having stirred up demons, I sought oblivion in these places
8.
Having stirred up demons, I sought oblivion in these places (5,4)
9.
Places frequented by Dorian Gray
10.
Haunts of the addicted, heartless men Oedipus ruined (5,4)
11.
High places?
12.
Demolished domes in UP - places to go on a trip (5,4)
13.
Impounds complex storing drugs in places for users (5,4)
14.
Drug centres strangely minus dope (5,4)