Across and Down

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There are 10 clues with the answer 'ONEANDDONE'
# CLUE
1.
Like a team that loses in the first round
2.
Single-use
3.
Never to be repeated
4.
Unable to drink much alcohol
5.
Not to be repeated
6.
Never again
7.
Like some NBA prospects, or like the answers to the starred clues
8.
Never tried another time
9.
Never to be repeated ... or an apt pronouncement after following the instructions sequentially in 17-, 25-, 39- and 49-Across?
10.
Apt idiom for an only child's parents