Across and Down

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There are 5 clues with the answer 'MYOSIS'
# CLUE
1.
Eye ailment: Var.
2.
My old relative's reaction to bright light
3.
Contraction of the pupil - Miss Yo (anag) (6)
4.
Excessive constriction of the pupils
5.
Give my little sister a ring - there's something wrong with the pupil