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There are 6 clues with the answer 'MADKEEN'
# CLUE
1.
Desperately anxious, pointing cryptically to knee? (3,4)
2.
Very eager for mother and daughter to have knee operation (3,4)
3.
Very eager to mourn after old lady died
4.
Extremely eager (3,4)
5.
Very excited to make end different
6.
Informally, very enthusiastic