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There are 4 clues with the answer 'GETSTHENEEDLE'
# CLUE
1.
Is inoculated and becomes very irritable (4,3,6)
2.
Suffers some irritation and receives an injection (4,3,6)
3.
Receives an injection and is annoyed (4,3,6)
4.
Becomes piqued and is given a shot (4,3,6)