Across and Down

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There are 4 clues with the answer 'GENETICMUTATION'
# CLUE
1.
A what is believed to be the likely cause behind the bent up Aspen grove at #43-Across?: 2 wds.
2.
GET NICE
3.
Change studied by evolutionary biologists, or what can be found in the answer to each starred clue?
4.
Evolutionary biologist's concern