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There are 27 clues with the answer 'EMASCULATES'
# CLUE
1.
Weakens seriously? Seems to be an actual problem (11)
2.
Deprives of vigour
3.
Weakens
4.
Upsets
5.
Unstrings
6.
Unsexes
7.
Unnerves
8.
Unmans
9.
Tires
10.
Sterilizes
11.
Softens
12.
Reduces
13.
Neuters
14.
Mutilates
15.
Makes
16.
Incapacitates
17.
Impoverishes
18.
Gelds
19.
Fixes
20.
Enervates
21.
Devitalizes
22.
Desexes
23.
Deprives
24.
Debilitates
25.
Cripples
26.
Castrates
27.
Alters