Across and Down

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There are 50 clues with the answer 'DOWNERS'
# CLUE
1.
Bad pills
2.
Sleeping pills, e.g.
3.
Drugs that aren't stimulants in slang
4.
500 proprietors' bad experiences (7)
5.
Depressants (7)
6.
They're a drag
7.
Depressing things
8.
Buzzkills
9.
From pills, died in front of shareholders (7)
10.
Finally arrested those having benzodiazepines and the like (7)
11.
Mood killers
12.
Worries
13.
WETS
14.
Unhappinesses
15.
Tribulations
16.
Tragedys
17.
Tragedies
18.
Slumps
19.
Sleeping pills, for example
20.
Sedatives
21.
Sadnesses
22.
Poors
23.
Pharmaceutical wonders
24.
Pessimists
25.
Nuisances
26.
Narcotics
27.
Melancholies
28.
Letdowns
29.
Hardships
30.
Frustrations