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There are 16 clues with the answer 'DISAFFECTS'
# CLUE
1.
Makes unfriendly fists, faced with trouble
2.
Weans
3.
Upsets
4.
Repels
5.
Estranges
6.
Divides
7.
Disunites
8.
Disturbs
9.
Disquiets
10.
Discomposes
11.
Breaks
12.
Antagonizes
13.
Aliens
14.
Alienates
15.
Agitates
16.
Insult full of emotion causes estrangement