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There are 22 clues with the answer 'CANNIEST'
# CLUE
1.
Most careful and shrewd
2.
Stance in reforms, most prudent (8)
3.
Superlatively skilful, refined ancients (8)
4.
An insect on the move, most cautious (8)
5.
Most clever ancients adapted (8)
6.
Shrewdest accountant playing tennis (8)
7.
Shrewdest actors accepting nine parts at random (8)
8.
Superlatively clever as an anagram for instance?
9.
Superlatively clever as an anagram for instance? (8)
10.
Show girl's seen in court to be more wily than the rest
11.
Instance (anag) (8)
12.
Shrewdest
13.
Savagest
14.
Most shrewd or frugal
15.
Most shrewd
16.
Most prudent
17.
Most ingenious
18.
Most cagey
19.
Beastliest
20.
Ancients' brews, sharper than the rest (8)
21.
For instance, an anagram that's shrewd in the extreme
22.
Most self-interested and shrewd