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There are 5 clues with the answer 'ASTRINGENTLY'
# CLUE
1.
In an austere manner
2.
Trains roughly, then moderately, with invigorating effect
3.
American series on hospital department initially leaving you in a severe way (12)
4.
Line for playing on, put in neatly, properly and austerely (12)
5.
Severely modified trains using little energy?