| DRED | Scott of an 1856 |
| SCRIVENER | Profession of the eponymous Bartleby in an 1856 short story by Herman Melville (9) |
| DREDSCOTT | Name in an 1856 case |
| RARE | Like an 1856 Flying Eagle cent |
| KEIR | Name shared by a Scottish trade unionist, 1856- 1915, one of the founders of Britain's Labour Party, and the current leader of that party (4) |
| EBB | 1856: Monogram of the English writer of Aurora Leigh |
| OPIUMWAR | Second _ _, colonial conflict of 1856-60, between the British and French empires and the Qing dynasty of China (5,3) |
| AVOGADRO | Amedeo ___ (1776-1856), Italian physicist whose eponymous law states that equal volumes of all gases at the same temperature and pressure contain equal numbers of molecules (8) |
| IVANTURGENEV | Russian author of novels including Rudin (1856) |
| AFTERDARK | 1856 collection of short stories by Wilkie Collins |
| CRIMEANWAR | Conflict ended by the 1856 Treaty of Paris |
| OPIUM | ___ Wars, conflicts of 1839-42 and 1856-60 |
| TURGENEV | Russian author of novels including Rudin (1856) |
| FLAUBERT | Gustave ........, author of Madame Bovary (1856) (8) |
| OLDS | Princely state of north-central India, annexed by Britain in 1856 |
| OUDH | Princely state of north-central India, annexed by Britain in 1856 |
| GIBBONS | Stanley, English stamp dealer who founded an authoritative stamp catalogue in 1856 (7) |
| BURBERRY | Thomas, English gentlemen's outfitter who founded an outdoor clothing company in 1856 (8) |
| NIKOLATESLA | Croatian-born US inventor (1856-1943) who gives his name to the derived SI unit of magnetic flux density (6,5) |
| FREUD | Sigmund ___ (1856 1931), Austrian neurologist, the founder of psychoanalysis (5) |
