| CURTISMARTIN | Patriots/Jets running back who's #4 in NFL career rushing yards: 2 wds. |
| LADAINIAN | With 43-Across, Chargers and Jets running back who will be inducted into the Pro Football Hall of Fame on August 5 |
| BARRYSANDERS | Lions running back who's #3 in NFL career rushing yards: 2 wds. |
| WALTERPAYTON | Bears running back who's #2 in NFL career rushing yards, behind Emmitt Smith: 2 wds. |
| REGGIEBUSH | NFL running back who forfeited his 2005 Heisman Trophy |
| TIKIBARBER | Giants running back who explained "quest" on "Sesame Street" in 2009: 2 wds. |
| MARSHAWNLYNCH | Beast Mode running back who came out of retirement in 2017 to play for the Oakland Raiders: 2 wds. |
| MARKINGRAMJR | Texans running back who won the 2009 Heisman Trophy as a sophomore at Alabama: 3 wds. |
| DERRICKHENRY | Titans running back who won the 2015 Heisman Trophy as a junior at Alabama: 2 wds. |
| TONYDORSETT | Hall of Fame Cowboys/Broncos running back who won the 1976 Heisman Trophy and the 1978 Super Bowl: 2 wds. |
| MARCUSALLEN | Hall of Fame Raiders/Chiefs running back who won the 1981 Heisman Trophy and the 1984 Super Bowl: 2 wds. |
| GALESAYERS | '60s-'70s Chicago Bears running back who is the youngest inductee into the Pro Football Hall of Fame |
| ENO | ___ Benjamin, current NFL running back who was a two-time All-Pac 12 first-team selection at Arizona State |
| ADRIANPETERSON | Vikings running back who gained 296 total yards in a 2007 NFL game, the most ever: 2 wds. |
| JEROMEHARRISON | Browns running back who gained 286 total yards in a 2009 NFL game, the third-most ever: 2 wds. |
| FRANCO | Pittsburgh Steelers running back who made the legendary "Immaculate Reception" |
| TAILBACK | (Football) The running back who plays the fullback position on the offensive team (8) |
| LAGGARD | Pull lass back who's last in line? (7) |
| LACK | The shortcoming of a left back who's lost his head (4) |
| JAMAL | With 40-Across, Ravens running back who gained 295 total yards in a 2003 NFL game, the second-most ever |
