| MOUSE | Hand-controlled electromechanical device for interacting with a digital computer that has a graphical user interface. It can be moved around on a flat surface to control the movement of a cursor. (5) |
| LIGHTPEN | Device for interacting with a computer screen |
| FINGER | Index needed for a digital computer? |
| CYBORG | Human being whose body has been taken over in whole or in part by electromechanical devices (6) |
| CYBORGS | Humans whose bodies have been taken over by electromechanical devices (7) |
| MICROPROCESSOR | Miniature electronic device that contains the arithmetic, logic, and control circuitry that performs the functions of a digital computer's central processing unit. (14) |
| CLIENTAPPLICATION | Program interacting with a remote server [1993] |
| ENDUSER | Person interacting with a product, ultimately |
| GEOTAG | Bit of metadata that might go with a digital photo |
| VTUBER | Twitch streamer with a digital avatar, say |
| KNUCKLE | Joint with a digital location? (7) |
| CROWDWORK | Part of a stand-up routine that involves interacting with the audience |
| ENGAGINGLY | Charmingly interacting with lady dropping leaflet, for example |
| GUILTCOMPLEX | Way of interacting with PC - officer - involved sense of remorse |
| ACTIN | Protein forming thin contractile filaments within muscle fibre, interacting with myosin (5) |
| SATURN | Ringed planet heard in this clip interacting with its moon Enceladus through plasma waves |
| OCCLUDEDFRONT | Conductor interacting with field, releasing current, may result in electrical discharge (8,5) |
| TAPE | Narrow strip or band for tying / to record sound, video material, digital computer data |
| BABBAGE | Charles, English mathematician born in 1791 credited with having conceived the first automatic digital computer (7) |
| ATANASOFF | With Clifford Berry, he developed the first electronic digital computer |
