| PEAK | Dr Jack Kerruish was the first of many doctors in which British TV series? (4,8) |
| PRACTICE | Dr Jack Kerruish was the first of many doctors in which British TV series? (4,8) |
| TAGGART | DCI Mike Jardine and DS Jackie Reed moved to centre stage in which British TV police drama after the death of the main character? (7) |
| EXTRAS | Many doctors in "Grey's Anatomy" |
| GRANADA | In the 1980s, which British TV company opened its studios to the public, creating a major tourist attraction? (7) |
| MEDICAL | Like the profession of many doctors |
| AQUARIA | Features of many doctor's office waiting rooms |
| AETNA | Handler of many doctor bills |
| SATELLITES | Sputnik 1 launched into orbit by Russia in 1957 was the first of many such space craft |
| WINCHESTER | The "Model 1866" of which rifle was the first of several models over the following decades? (10) |
| TELETEXT | TV series of which BBC's Ceefax was the first of its kind (8) |
| CHAUCER | The Canterbury Tales author, who was the first of the poets to be buried in Poets' Corner in Westminster Abbey (7) |
| WESTSIDESTORY | Film which in 1962 was the first of four musicals to win the Best Picture Oscar during the 1960s (4,4,5) |
| ATOMIC | The Nautilus, launched in 1954, was the first of this kind of submarine |
| SCORSESE | Academy Award-winning director whose 1974 crime drama Mean Streets was the first of many collaborations with Robert De Niro (8) |
| RUMPOLE | Leo McKern played an eccentric barrister in the long-running British TV series ... Of The Bailey |
| OPENINGNIGHT | The possibility of a job at sea? Thing is, it's all for show - the first of many if those play-actors are successful? (7,5) |
| REFORM | The ... Club in Pall Mall was the first of the old London clubs to admit women as members (6) |
| LAPTOP | The Osborne 1 was the first of this type of computer to go on sale, in April 1981 (6) |
| HAMSTER | Animal the first of many in a hurry beginning to run (7) |
