| VIRGIN | A Madonna (6) |
| PRAYER | Like a -, Madonna hit (6) |
| TRUEBLUE | A Spandau Ballet song, a Joni Mitchell song and a Madonna song (4,4) |
| PAPA | First word in the title of a Madonna hit |
| RAPHAEL | One who designed many a madonna and archangel (7) |
| SUSAN | She's desperately sought in a Madonna movie |
| MATERIALWORLD | *What "we are living in," per a Madonna hit song |
| RIPA | Morning-television host Kelly who was recently invited onstage at a Madonna concert |
| ALIG | Sacha Baron Cohen character who was featured in a Madonna music video |
| WHITE | Pale hue of a Madonna-lily; or, the colour of one's liver, when one is said to be pusillanimous or lily-livered (5) |
| RAYOF | (and 4 Down) Faith and glory somehow combining in a Madonna hit (3,2,5) |
| REDCAP | Depicted in a number of Madonna paintings, a name for the thistle eating goldfinch or "thisteltuige" (6) |
| LEAGUE | 'A -- of Their Own', 1992 film starring Tom Hanks, Geena Davis, and Madonna (6) |
| MARLEY | Madonna covering the French reggae star (6) |
| FROZEN | Madonna song about a popsicle? |
| PREACH | Papa Don't -, 1986 Madonna song (6) |
| LAISLA | Madonna hit from 1986 (2,4,6) |
| BONITA | Madonna hit from 1986 (2,4,6) |
| GROOVE | Into the - - -, Madonna hit from 1985 (6) |
| CHERUB | Any one of the angelic beings depicted on Raphael's altarpiece Sistine Madonna (6) |
